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| ROLE OF RESIDUAL CALCIUM IN SYNAPTIC DEPRESSION AND POSTTETANIC POTENTIATION - FAST AND SLOW CALCIUM SIGNALING IN NERVE-TERMINALS |
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| Author(s): SWANDULLA D, HANS M, ZIPSER K, AUGUSTINE GJ |
| Source: NEURON Volume: 7 Issue: 6 Pages: 915-926 Published: DEC 1991 |
| Times Cited: 168 References: 59 |
| Abstract: Trains of action potentials evoked rises in presynaptic Ca2+ concentration ([Ca2+]i) at the squid giant synapse. These increases in [Ca2+]i were spatially nonuniform during the trains, but rapidly equilibrated after the trains and slowly declined over hundreds of seconds. The trains also elicited synaptic depression and augmentation, both of which developed during stimulation and declined within a few seconds afterward. Microinjection of the Ca2+ buffer EGTA into presynaptic terminals had no effect on transmitter release or synaptic depression. However, EGTA injection effectively blocked both the persistent Ca2+ signals and augmentation. These results suggest that transmitter release is triggered by a large, brief, and sharply localized rise in [Ca2+]i, while augmentation is produced by a smaller, slower, and more diffuse rise in [Ca2+]i. |
| Document Type: Article |
| Language: English |
| Reprint Address: SWANDULLA, D (reprint author), MAX PLANCK INST BIOPHYS CHEM, W-3400 GOTTINGEN, GERMANY |
Addresses:
1. MARINE BIOL LAB, WOODS HOLE, MA 02543 USA
2. DUKE UNIV, MED CTR, DEPT NEUROBIOL, DURHAM, NC 27710 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Neurosciences |
| IDS Number: GY438 |
| ISSN: 0896-6273 |
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