| POSTSYNAPTIC CONTRIBUTION TO LONG-TERM POTENTIATION REVEALED BY THE ANALYSIS OF MINIATURE SYNAPTIC CURRENTS |
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| Author(s): MANABE T, RENNER P, NICOLL RA |
| Source: NATURE Volume: 355 Issue: 6355 Pages: 50-55 Published: JAN 2 1992 |
| Times Cited: 258 References: 34 |
| Abstract: Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV CALIF SAN FRANCISCO, DEPT PHARMACOL, SAN FRANCISCO, CA 94143 USA
2. UNIV CALIF SAN FRANCISCO, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: GY228 |
| ISSN: 0028-0836 |