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| EFFECTIVE CHEMOTHERAPY FOR MELANOMA AFTER TREATMENT WITH INTERLEUKIN-2 |
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| Author(s): RICHARDS JM, GILEWSKI TA, RAMMING K, MITCHEL B, DOANE LL, VOGELZANG NJ |
| Source: CANCER Volume: 69 Issue: 2 Pages: 427-429 Published: JAN 15 1992 |
| Times Cited: 40 References: 11 |
| Abstract: Twenty patients with biopsy-proven metastatic malignant melanoma, previously treated with interleukin-2 (IL-2), received combination chemotherapy for progressive disease. Treatment included carmustine, cisplatin, dacarbazine, and tamoxifen (BCDT). Nausea was the most common toxicity (100%) and usually was mild. Persistent thrombocytopenia was the most frequent toxicity limiting further treatment. Eleven patients (55%) had an objective partial response, three patients (15%) had a minor response, and six patients (30%) had no change or progressive disease in response to this treatment. These results were comparable to the high response rates (21 of 40, 53%) achieved with BCDT in previously untreated patients with melanoma. It was concluded that prior therapy using IL-2 does not significantly alter the response rate of metastatic melanoma to BCDT, thus suggesting that immunomodulators (e.g., IL-2) and chemotherapeutic agents are not cross-resistant treatments. |
| Document Type: Article |
| Language: English |
| Reprint Address: RICHARDS, JM (reprint author), UNIV CHICAGO, DEPT MED, HEMATOL ONCOL SECT, 5841 S MARYLAND AVE, BOX 420, CHICAGO, IL 60637 USA |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Oncology |
| IDS Number: GY837 |
| ISSN: 0008-543X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |