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| FOLLICULAR DENDRITIC CELLS ARE A MAJOR RESERVOIR FOR HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN LYMPHOID-TISSUES FACILITATING INFECTION OF CD4+ T-HELPER CELLS |
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| Author(s): SPIEGEL H, HERBST H, NIEDOBITEK G, FOSS HD, STEIN H |
| Source: AMERICAN JOURNAL OF PATHOLOGY Volume: 140 Issue: 1 Pages: 15-22 Published: JAN 1992 |
| Times Cited: 178 References: 33 |
| Abstract: Human immunodeficiency virus type 1 (HIV-1) infection causes progressive depletion of CD4/HIV-receptor-positive T helper lymphocytes, ultimately leading to AIDS. The major HIV reservoir and site of T-helper cell infection in lymphoid tissues, however, has remained poorly defined. The authors used in situ hybridization in combination with immunohistologic labeling techniques to identify the phenotype of HIV-infected cells in lymph nodes from patients at different stages of HIV-infection. The number of HIV-infected macrophages, widely considered the major site of HIV replication, was extremely low. There was no evidence for HIV-infection of endothelial and interdigitating reticulum cells. However, HIV RNA was found in small but consistent proportions of CD45RO-positive T cells and in the vast majority of follicular dendritic cells (FDC) in a pattern suggestive of active infection in addition to HIV-immunocomplex trapping on cell membranes. FDC may therefore be a major HIV reservoir and since T-helper cells travel through the FDC meshwork during their migration within lymphoreticular tissues, it appears likely that HIV-replicating T cells may infect FDC, which then infect new T cells, thus causing a gradual dissemination of the virus to all FDC and thereby a steadily increasing infection of T-helper/memory cells within germinal centers. This results in CD4+ T cell depletion, and ultimately, in immunodeficiency. |
| Document Type: Note |
| Language: English |
Addresses:
1. FREE UNIV BERLIN, KLINIKUM STEGLITZ, INST PATHOL, HINDENBURGDAMM 30, W-1000 BERLIN 45, GERMANY |
| Publisher: AMER SOC INVESTIGATIVE PATHOLOGY, INC, 428 EAST PRESTON ST, BALTIMORE, MD 21202-3993 |
| Subject Category: Pathology |
| IDS Number: GZ636 |
| ISSN: 0002-9440 |
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