| | |  | | | | Record from Web of Science® | | | | | | |
| ACTIN-BINDING PROTEIN REQUIREMENT FOR CORTICAL STABILITY AND EFFICIENT LOCOMOTION |
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| Author(s): CUNNINGHAM CC, GORLIN JB, KWIATKOWSKI DJ, HARTWIG JH, JANMEY PA, BYERS HR, STOSSEL TP |
| Source: SCIENCE Volume: 255 Issue: 5042 Pages: 325-327 Published: JAN 17 1992 |
| Times Cited: 328 References: 30 |
| Abstract: Three unrelated tumor cell lines derived from human malignant melanomas lack actin-binding protein (ABP), which cross-links actin filaments in vitro and connects these filaments to plasma membrane glycoproteins. The ABP-deficient cells have impaired locomotion and display circumferential blebbing of the plasma membrane. Expression of A.BP in one of the lines after transfection restored translocational motility and reduced membrane blebbing. These findings establish that ABP functions to stabilize cortical actin in vivo and is required for efficient cell locomotion. |
| Document Type: Article |
| Language: English |
| Reprint Address: CUNNINGHAM, CC (reprint author), HARVARD UNIV, BRIGHAM & WOMENS HOSP, SCH MED, DEPT MED, DIV EXPTL MED, BOSTON, MA 02115 USA |
Addresses:
1. HARVARD UNIV, BRIGHAM & WOMENS HOSP, SCH MED, DEPT MED, DIV HEMATOL ONCOL, BOSTON, MA 02115 USA
2. MASSACHUSETTS GEN HOSP, DEPT PATHOL, BOSTON, MA 02114 USA
3. HARVARD UNIV, SCH MED, DANA FARBER CANC INST, CHILDRENS HOSP, DEPT HEMATOL ONCOL, DIV PEDIAT ONCOL, BOSTON, MA 02115 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: GZ695 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |