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| CONTROL OF SCARRING IN ADULT WOUNDS BY NEUTRALIZING ANTIBODY TO TRANSFORMING GROWTH-FACTOR-BETA |
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| Author(s): SHAH M, FOREMAN DM, FERGUSON MWJ |
| Source: LANCET Volume: 339 Issue: 8787 Pages: 213-214 Published: JAN 25 1992 |
| Times Cited: 402 References: 10 |
| Abstract: Adult wounds heal with scar-tissue formation, whereas fetal wounds heal without scarring and with a lesser inflammatory and cytokine response. We injected the margins of healing dermal wounds in adult rats with neutralising antibody (NA) to transforming growth factor-beta (TGF-beta). All control wounds (irrelevant antibody, or TGF-beta, or no injection) healed with scarring, whereas the NA-treated wounds healed without scar-tissue formation; NA-treated wounds had fewer macrophages and blood vessels, lower collagen and fibronectin contents, but identical tensile strength and more normal dermal architecture than the other wounds. Early manipulation of the concentrations of selected cytokines may be a new approach to the control of scarring. |
| Document Type: Note |
| Language: English |
Addresses:
1. UNIV MANCHESTER, SCH BIOL SCI, DEPT CELL & STRUCT BIOL, STOPFORD BLDG, MANCHESTER M13 9PT, LANCS ENGLAND |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: HA589 |
| ISSN: 0140-6736 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |