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| LOW-GRADE GASTRIC B-CELL LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID-TISSUE (MALT) - A MULTIFOCAL DISEASE |
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| Author(s): WOTHERSPOON AC, DOGLIONI C, ISAACSON PG |
| Source: HISTOPATHOLOGY Volume: 20 Issue: 1 Pages: 29-34 Published: JAN 1992 |
| Times Cited: 110 References: 19 |
| Abstract: Gastrectomy specimens from five patients following gastroscopic biopsies which showed low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) were examined by serially sectioning and paraffin wax embedding using a 'swiss roll' technique. This procedure allowed the construction of a map of the specimen on which the distribution of the lymphoma could be plotted. In each case confluent lymphoma was identified. In addition small foci of lymphoma consisting of 1-4 lymphoid follicles surrounded by neoplastic centrocyte-like cells were seen. The positions of these 'micro-lymphomas' were plotted on the gastrectomy maps, showing multiple foci distributed throughout the gastric mucosa. The identification of these microscopic lesions may explain the development of local relapse, often after a long disease-free interval, in patients with gastric MALT lymphoma treated by partial gastrectomy where excision appears to have been complete. Patients treated in this way should, therefore, be followed-up indefinitely, with regular endoscopy and gastric biopsy, in order to identify early local disease relapse. |
| Document Type: Article |
| Language: English |
| Reprint Address: WOTHERSPOON, AC (reprint author), UNIV COLL & MIDDLESEX SCH MED, DEPT HISTOPATHOL, UNIV ST, LONDON WC1E 6JJ, ENGLAND |
Addresses:
1. OSPED CIVILE, SERV ANAT, FELTRE, ITALY |
| Publisher: BLACKWELL SCIENCE LTD, OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL |
| Subject Category: Cell Biology; Pathology |
| IDS Number: HA642 |
| ISSN: 0309-0167 |
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