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| A FAMILY OF METABOTROPIC GLUTAMATE RECEPTORS |
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| Author(s): TANABE Y, MASU M, ISHII T, SHIGEMOTO R, NAKANISHI S |
| Source: NEURON Volume: 8 Issue: 1 Pages: 169-179 Published: JAN 1992 |
| Times Cited: 845 References: 39 |
| Abstract: Three cDNA clones, mGluR2, mGluR3, and mGLuR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA-transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns. |
| Document Type: Article |
| Language: English |
| Reprint Address: TANABE, Y (reprint author), KYOTO UNIV, FAC MED, INST IMMUNOL, KYOTO 606, JAPAN |
Addresses:
1. KYOTO UNIV, FAC MED, DEPT MORPHOL BRAIN SCI, KYOTO 606, JAPAN |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Neurosciences |
| IDS Number: HB185 |
| ISSN: 0896-6273 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |