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| INTRARECTAL CHALLENGE OF MACAQUES VACCINATED WITH FORMALIN-INACTIVATED SIMIAN IMMUNODEFICIENCY VIRUS |
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| Author(s): CRANAGE MP, BASKERVILLE A, ASHWORTH LAE, DENNIS M, COOK N, SHARPE S, FARRAR G, ROSE J, KITCHIN PA, GREENAWAY PJ |
| Source: LANCET Volume: 339 Issue: 8788 Pages: 273-274 Published: FEB 1 1992 |
| Times Cited: 79 References: 7 |
| Abstract: Macaques can be protected from intravenous infection with simian immunodeficiency virus (SIV) by vaccination with chemically inactivated virus. However, protection against infection via a mucosal surface has not been demonstrated. We vaccinated four rhesus macaques with formalin-inactivated SIV given intramuscularly. These monkeys, which had remained virus free for 10 months after intravenous challenge with SIV, were given a further dose of vaccine and together with four unvaccinated controls were challenged intrarectally with SIV. Subsequently, virus was isolated from all control animals on five successive occasions, but the vaccinated animals remained free of virus. Proviral DNA could not be detected in peripheral blood mononuclear cells from the vaccinated animals. Preliminary data indicate that vaccinated animals make a local antibody response. |
| Document Type: Note |
| Language: English |
| Reprint Address: CRANAGE, MP (reprint author), PUBL HLTH LAB SERV, CTR APPL MICROBIOL & RES, DIV PATHOL, PORTON DOWN SP4 0JG, WILTS ENGLAND |
Addresses:
1. NATL INST BIOL STAND & CONTROLS, PCR REFERENCE LAB, POTTERS BAR, HERTS ENGLAND |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: HB529 |
| ISSN: 0140-6736 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |