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| RETINOID X-RECEPTOR INTERACTS WITH NUCLEAR RECEPTORS IN RETINOIC ACID, THYROID-HORMONE AND VITAMIN-D3 SIGNALING |
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| Author(s): KLIEWER SA, UMESONO K, MANGELSDORF DJ, EVANS RM |
| Source: NATURE Volume: 355 Issue: 6359 Pages: 446-449 Published: JAN 30 1992 |
| Times Cited: 1,170 References: 21 |
| Abstract: CELLULAR responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically distinct 1 families of receptors: the retinoic acid receptors (RAR) 2,3 and the retinoid X receptors (RXR) 1. Here we report that the transcriptional activity of RAR and RXR can be reciprocally modulated by direct interactions between the two proteins. RAR and RXR have a high degree of cooperativity in binding to target DNA, consistent with previous reports indicating that the binding of either RAR or RXR to their cognate response elements is enhanced by factors present in nuclear extracts 4,5. RXR also interacts directly with and enhances the binding of nuclear receptors conferring responsiveness to vitamin D3 and thyroid hormone T3; the DNA-binding activities of these receptors are also stimulated by the presence of nuclear extracts 6-9. Together these data indicate that RXR has a central role in multiple hormonal signalling pathways. |
| Document Type: Article |
| Language: English |
| Reprint Address: KLIEWER, SA (reprint author), SALK INST BIOL STUDIES, LA JOLLA, CA 92037 USA |
Addresses:
1. HOWARD HUGHES MED INST, LA JOLLA, CA 92037 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: HB530 |
| ISSN: 0028-0836 |
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