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| PRESENTATION OF VIRAL-ANTIGEN BY MHC CLASS-I MOLECULES IS DEPENDENT ON A PUTATIVE PEPTIDE TRANSPORTER HETERODIMER |
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| Author(s): SPIES T, CERUNDOLO V, COLONNA M, CRESSWELL P, TOWNSEND A, DEMARS R |
| Source: NATURE Volume: 355 Issue: 6361 Pages: 644-646 Published: FEB 13 1992 |
| Times Cited: 301 References: 28 |
| Abstract: MAJOR histocompatibility complex (MHC) class I molecules present peptides derived from the endogenous protein pool to cytotoxic T lymphocytes, which can thus recognize intracellular antigen 1-3 . This pathway may depend on a transporter (PSF1) (refs 4-6) to mediate entry of the cytosolic peptides into a pre-Golgi compartment where they bind to class I heavy chains and promote their stable assembly with beta-2-microglobulin 7-12. There is, however, only indirect support for this function of PSF1 (ref. 6). Here we show that PSF1 is necessary for the efficient assembly of class I molecules and enables them to present a peptide epitope derived from endogenously synthesized viral antigen. Immunochemical and genetic data demonstrate that the PSF1 polypeptide is associated with a complementary transporter chain, which is polymorphic and is encoded by the PSF2 gene 13, which is closely linked to PSF1. |
| Document Type: Article |
| Language: English |
| Reprint Address: SPIES, T (reprint author), HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DIV TUMOR VIROL, 44 BINNEY ST, BOSTON, MA 02115 USA |
Addresses:
1. JOHN RADCLIFFE HOSP, INST MOLEC MED, OXFORD OX3 9DU, ENGLAND
2. IST NAZL RIC CANC, I-16132 GENOA, ITALY
3. YALE UNIV, SCH MED, IMMUNOBIOL SECT, NEW HAVEN, CT 06510 USA
4. UNIV WISCONSIN, GENET LAB, MADISON, WI 53706 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: HD547 |
| ISSN: 0028-0836 |
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