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| MUPIROCIN TREATMENT OF NASAL STAPHYLOCOCCAL COLONIZATION |
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| Author(s): SCULLY BE, BRIONES F, GU JW, NEU HC |
| Source: ARCHIVES OF INTERNAL MEDICINE Volume: 152 Issue: 2 Pages: 353-356 Published: FEB 1992 |
| Times Cited: 40 References: 31 |
| Abstract: The effectiveness and safety of mupirocin calcium ointment applied to the anterior part of the nares for 5 days in the eradication of nasal carriage of Staphylococcus aureus was investigated in a placebo-controlled, double-blind study. Subjects were healthy medical center staff who had two positive cultures of the anterior nares for S aureus. Antimicrobial susceptibility, phage typing, and restriction endonuclease analysis of plasmid DNA were used to monitor the identity of relapsing and persisting strains. Mupirocin eliminated 74% of S aureus at early follow-up and 91% of original strains. At 4 weeks, 78% of the original strains were eradicated, whereas all of the placebo group remained colonized. Recolonization with mupirocin-resistant strains occurred in six patients, but these were of different phage and plasmid types from the original isolates. None of the subjects had serious adverse effects. Applied intranasally for 5 days, a calcium preparation of mupirocin in a paraffin base is effective in eliminating S aureus nasal carriage and is well tolerated. |
| Document Type: Article |
| Language: English |
| Reprint Address: SCULLY, BE (reprint author), COLUMBIA UNIV COLL PHYS & SURG, DEPT MED, 630 W 168TH ST, NEW YORK, NY 10032 USA |
Addresses:
1. COLUMBIA UNIV COLL PHYS & SURG, DEPT PHARMACOL, NEW YORK, NY 10032 USA |
| Publisher: AMER MEDICAL ASSOC, 515 N STATE ST, CHICAGO, IL 60610 |
| Subject Category: Medicine, General & Internal |
| IDS Number: HE069 |
| ISSN: 0003-9926 |
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