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| EFFECTS OF CPT-11 IN COMBINATION WITH OTHER ANTICANCER AGENTS IN CULTURE |
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| Author(s): KANO Y, SUZUKI K, AKUTSU M, SUDA K, INOUE Y, YOSHIDA M, SAKAMOTO S, MIURA Y |
| Source: INTERNATIONAL JOURNAL OF CANCER Volume: 50 Issue: 4 Pages: 604-610 Published: FEB 20 1992 |
| Times Cited: 201 References: 39 |
| Abstract: CPT-11, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy camptothecin, is a newly developed water-soluble camptothecin derivative now undergoing phase-II evaluation. In an attempt to establish whether the combination of CPT-11 with other standard anti-cancer agents would be of any benefit, we studied the effects of CPT-11 in combination with II other anti-cancer agents on a human T-cell leukemia cell line, MOLT-3, in culture. We used both CPT-11 and SN-38 (active substance of CPT-11 in vivo), for our study. Cells were incubated for 3 days in the presence of 2 drugs (CPT-11 or SN-38 and another drug) and cytotoxic effects were determined by MTT assay. The effects of drug combinations on ID50 were analyzed by an improved isobologram method. Supra-additive and marginal supra-additive effects (synergism) were observed for CPT-11 in combination with cisplatin, cytosine arabinoside and mitomycin C. Additive effects were observed for its combination with amsacrine, bleomycin, doxorubicin, etoposide, 5-fluorouracil, mitoxantrone and vincristine. Alternate sub-additive and protective effects (antagonism) were observed for CPT-11 in combination with methotrexate. Similar tendencies were observed for SN-38 in combination with other agents. These results suggest that CPT-11 in simultaneous administration with a majority of anti-cancer agents has an advantage for cytokilling. Of these agents, cisplatin, cytosine arabinoside and mitomycin C are most suitable for simultaneous administration with CPT-11. |
| Document Type: Article |
| Language: English |
| Reprint Address: KANO, Y (reprint author), TOCHIGI CANC CTR, DIV MED ONCOL, UTSUNOMIYA, TOCHIGI 320 JAPAN |
Addresses:
1. TOCHIGI CANC CTR, DIV CLIN PATHOL, UTSUNOMIYA, TOCHIGI 320 JAPAN
2. TOCHIGI CANC CTR, DIV SURG, UTSUNOMIYA, TOCHIGI 320 JAPAN
3. JICHI MED SCH, DEPT HEMATOL, MINAMI KAWACHI, TOCHIGI 32014 JAPAN |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Oncology |
| IDS Number: HF454 |
| ISSN: 0020-7136 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |