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| ABSENCE OF LINKAGE OF NOONAN SYNDROME TO THE NEUROFIBROMATOSIS TYPE-1 LOCUS |
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| Author(s): SHARLAND M, TAYLOR R, PATTON MA, JEFFERY S |
| Source: JOURNAL OF MEDICAL GENETICS Volume: 29 Issue: 3 Pages: 188-190 Published: MAR 1992 |
| Times Cited: 22 References: 21 |
| Abstract: Eleven families with Noonan syndrome in either two or three generations have been identified. Following the reports of subjects with features of both Noonan syndrome and neurofibromatosis type 1, these pedigrees have been studied using a number of probes at the neurofibromatosis type 1 locus (17q11). A significantly negative lod score was obtained with the intragenic probe NF1-C2, suggesting that the genes for Noonan syndrome and neurofibromatosis type 1 are not contiguous. |
| Document Type: Article |
| Language: English |
| Reprint Address: SHARLAND, M (reprint author), ST GEORGE HOSP, SCH MED, SW THAMES REG GENET SERV, CRANMER TERRACE, LONDON SW17 0RE, ENGLAND |
| Publisher: BRITISH MED JOURNAL PUBL GROUP, BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON, ENGLAND WC1H 9JR |
| Subject Category: Genetics & Heredity |
| IDS Number: HG625 |
| ISSN: 0022-2593 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |