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| ANTIMUTAGENIC EFFECTS OF RADIOPROTECTOR WR-2721 AGAINST FISSION-SPECTRUM NEUTRONS AND CO-60 GAMMA-RAYS IN MICE |
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| Author(s): KATAOKA Y, BASIC I, PERRIN J, GRDINA DJ |
| Source: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY Volume: 61 Issue: 3 Pages: 387-392 Published: MAR 1992 |
| Times Cited: 40 References: 27 |
| Abstract: The antimutagenic effects of the radiation protective agent, S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721), were studied against fission-spectrum-neutron- and Co-60-gamma-ray-induced mutagenesis in mice. Mutagenesis at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus was measured 56 days following whole-body irradiation with JANUS neutrons (single doses, 50-150 cGy) or Co-60 photons (single doses, 250-750 cGy). Splenic T lymphocytes from B6CF1 mice were grown in round-bottomed 96-microwell culture plates with or without the selective agent 6-thioguanine (6-TG). The mutant frequency, as a result of exposure to neutrons or Co-60 photons, increased 100-fold with dose. Doses of 150 cGy neutrons and 750 cGy Co-60 photons were equally mutagenic. When animals were injected with WR-2721 at a dose of 400 mg/kg body weight, i.p., 30 min before whole-body irradiation with JANUS neutrons or Co-60 photons, mutant frequencies were significantly reduced at all radiation doses (i.e. protection factors of 1.4 and 2.4, respectively). Thus, the aminothiols are effective antimutagens. A novel clinical application of these compounds could be in their use to protect against radiation- and/or chemotherapy-induced genotoxic damage to normal cells. |
| Document Type: Article |
| Language: English |
Addresses:
1. ARGONNE NATL LAB, DIV SOLID STATE PHYS, 9700 S CASS AVE, ARGONNE, IL 60439 USA
2. UNIV ZAGREB, DEPT ANIM PHYSIOL, YU-41000 ZAGREB, YUGOSLAVIA
3. UNIV CHICAGO, MED CTR, DEPT RADIAT & CELLULAR ONCOL, CHICAGO, IL 60637 USA |
| Publisher: TAYLOR & FRANCIS LTD, ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE |
| Subject Category: Biology; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging |
| IDS Number: HH194 |
| ISSN: 0955-3002 |
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