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| CLOSE LINKAGE OF GLUCOKINASE LOCUS ON CHROMOSOME-7P TO EARLY-ONSET NON-INSULIN-DEPENDENT DIABETES-MELLITUS |
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| Author(s): FROGUEL P, VAXILLAIRE M, SUN F, VELHO G, ZOUALI H, BUTEL MO, LESAGE S, VIONNET N, CLEMENT K, FOUGEROUSSE F, TANIZAWA Y, WEISSENBACH J, BECKMANN JS, LATHROP GM, PASSA P, PERMUTT MA, COHEN D |
| Source: NATURE Volume: 356 Issue: 6365 Pages: 162-164 Published: MAR 12 1992 |
| Times Cited: 377 References: 27 |
| Abstract: NON-INSULIN-DEPENDENT diabetes mellitus (NIDDM) is a major health problem, affecting 5% of the world population. Genetic factors are important in NIDDM, but the mechanisms leading to glucose intolerance are unknown 1,2. Genetic linkage has been investigated in multigeneration families to localize, and ultimately identify, the gene(s) predisposing to NIDDM. Here we report linkage between the glucokinase locus on chromosome 7p and diabetes in 16 French families with maturity-onset diabetes of the young, a form of NIDDM characterized by monogenic autosomal dominant transmission and early age of onset 3. Statistical evidence of genetic heterogeneity was significant, with an estimated 45-95% of the 16 families showing linkage to glucokinase. Because glucokinase is a key enzyme of blood glucose homeostasis 4, these results are evidence that a gene involved in glucose metabolism could be implicated in the pathogenesis of NIDDM. |
| Document Type: Article |
| Language: English |
| Reprint Address: FROGUEL, P (reprint author), CTR ETUD POLYMORPHISME HUMAIN, 27 RUE JULIETTE DODU, F-75010 PARIS, FRANCE |
Addresses:
1. HOP ST LOUIS, SERV ENDOCRINOL, F-75010 PARIS, FRANCE
2. GENETHON, F-91000 EVRY, FRANCE
3. INST PASTEUR, CNRS, F-75724 PARIS 15, FRANCE
4. INSERM, U358, F-75010 PARIS, FRANCE
5. WASHINGTON UNIV, SCH MED, DIV METAB, ST LOUIS, MO 63110 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: HH731 |
| ISSN: 0028-0836 |
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