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| POTASSIUM CHANNEL CONDUCTANCE - A MECHANISM AFFECTING HAIR-GROWTH BOTH INVITRO AND INVIVO |
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| Author(s): BUHL AE, WALDON DJ, CONRAD SJ, MULHOLLAND MJ, SHULL KL, KUBICEK MF, JOHNSON GA, BRUNDEN MN, STEFANSKI KJ, STEHLE RG, GADWOOD RC, KAMDAR BV, THOMASCO LM, SCHOSTAREZ HJ, SCHWARTZ TM, DIANI AR |
| Source: JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 98 Issue: 3 Pages: 315-319 Published: MAR 1992 |
| Times Cited: 44 References: 35 |
| Abstract: The opening of intracellular potassium channels has been suggested as a mechanism regulating hair growth. Enhancing the flux of potassium ions is a mechanism shared by several structurally diverse antihypertensive agents including minoxidil sulfate (the active metabolite of minoxidil), pinacidil, P-1075 (a potent pinacidil analog), RP-49,356, diazoxide, cromakalim, and nicorandil. Of these drugs, minoxidil, pinacidil, and diazoxide have been reported to elicit hypertrichosis in humans. This potassium channel hypothesis was examined by testing these drugs for effects on hair growth both in vitro and in vivo. For the in vitro studies, mouse vibrissae follicles were cultured for 3 d with drug and the effects on hair growth were measured by metabolic labeling. All drugs, except diazoxide, enhanced cysteine incorporation into the hair shafts of the cultured vibrissae. Diazoxide was poorly soluble and thus was tested only at low doses. Minoxidil, P-1075, cromakalim, and RP-49,356 were also evaluated in vivo by measuring hair growth effects in balding stumptail macaque monkeys. The drugs were administered topically to defined sites on balding scalps once per day for 4-5 months and the amount of hair grown was determined by monthly measurements of shaved hair weight. Three of the drugs produced significant increases in hair weight whereas, the RP-49,356 had no effect. These studies provide correlative evidence that the opening of potassium channels is an important regulatory mechanism for hair growth. This provides the impetus for further studies on this potentially important mechanism affecting hair biology. |
| Document Type: Article |
| Language: English |
| Reprint Address: BUHL, AE (reprint author), UPJOHN CO, DERMATOL RES, 301 HENRIETTA ST, KALAMAZOO, MI 49001 USA |
Addresses:
1. UPJOHN CO, BIOMATH, KALAMAZOO, MI 49001 USA
2. UPJOHN CO, MED CHEM RES, KALAMAZOO, MI 49001 USA
3. UPJOHN CO, PHARMACEUT, KALAMAZOO, MI 49001 USA |
| Publisher: BLACKWELL SCIENCE INC, 350 MAIN ST, MALDEN, MA 02148 |
| Subject Category: Dermatology |
| IDS Number: HJ638 |
| ISSN: 0022-202X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |