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| MICE DEFICIENT FOR P53 ARE DEVELOPMENTALLY NORMAL BUT SUSCEPTIBLE TO SPONTANEOUS TUMORS |
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| Author(s): DONEHOWER LA, HARVEY M, SLAGLE BL, MCARTHUR MJ, MONTGOMERY CA, BUTEL JS, BRADLEY A |
| Source: NATURE Volume: 356 Issue: 6366 Pages: 215-221 Published: MAR 19 1992 |
| Times Cited: 2,848 References: 52 |
| Abstract: Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null mutation was introduced into the gene by homologous recombination in murine embryonic stem cells. Mice homozygous for the null allele appear normal but are prone to the spontaneous development of a variety of neoplasms by 6 months of age. These observations indicate that a normal p53 gene is dispensable for embryonic development, that its absence predisposes the animal to neoplastic disease, and that an oncogenic mutant form of p53 is not obligatory for the genesis of many types of tumours. |
| Document Type: Article |
| Language: English |
| Reprint Address: DONEHOWER, LA (reprint author), BAYLOR COLL MED, DIV MOLEC VIROL, HOUSTON, TX 77030 USA |
Addresses:
1. BAYLOR COLL MED, CTR COMPARAT MED, HOUSTON, TX 77030 USA
2. BAYLOR COLL MED, INST MOLEC GENET, HOUSTON, TX 77030 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: HJ944 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |