| | |  | | | | Record from Web of Science® | | | | | | |
| THE MOLECULAR NECKLACE - A ROTAXANE CONTAINING MANY THREADED ALPHA-CYCLODEXTRINS |
|
|
| Author(s): HARADA A, LI J, KAMACHI M |
| Source: NATURE Volume: 356 Issue: 6367 Pages: 325-327 Published: MAR 26 1992 |
| Times Cited: 555 References: 13 |
| Abstract: THE importance of non-covalent interactions in biological systems motivates much of the current interest in supramolecular assemblies 1. A classic example of a supermolecule is provided by the rotaxanes 2-5, in which a molecular 'rotor' is threaded by a linear 'axle'. Previous examples have included cyclic crown ethers threaded by polymers 6, paraquat-hydroquinone complexes 7 and cyclodextrin complexes 8,9. We found recently that alpha-cyclodextrin will form high yields of a crystalline complex with polyethylene glycol (PEG), and suggested that the PEG penetrates the 'beaker-like' tunnel of the cyclodextrin 10,11. We report here the preparation of a compound in which several cyclodextrins are threaded on a single PEG chain and are trapped by capping the chain with bulky end groups. This brings a step closer the 'molecular abacus' proposed by Stoddart and coworkers 7. We call this supramolecular assembly a 'molecular necklace'. |
| Document Type: Article |
| Language: English |
| Reprint Address: HARADA, A (reprint author), OSAKA UNIV, FAC SCI, DEPT MACROMOLEC SCI, TOYONAKA, OSAKA 560 JAPAN |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: HK794 |
| ISSN: 0028-0836 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |