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| IMPROVED STENOSIS GEOMETRY BY QUANTITATIVE CORONARY ARTERIOGRAPHY AFTER VIGOROUS RISK FACTOR MODIFICATION |
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| Author(s): GOULD KL, ORNISH D, KIRKEEIDE R, BROWN S, STUART Y, BUCHI M, BILLINGS J, ARMSTRONG W, PORTS T, SCHERWITZ L |
| Source: AMERICAN JOURNAL OF CARDIOLOGY Volume: 69 Issue: 9 Pages: 845-853 Published: APR 1 1992 |
| Times Cited: 69 References: 35 |
| Abstract: This study is a randomized, controlled, blinded, arteriographic trial to determine the effects of a low-cholesterol, low-fat, vegetarian diet, stress management and moderate aerobic exercise on geometric dimensions, shape and fluid dynamic characteristics of coronary artery stenoses in humans. Complex changes of different primary stenosis dimensions in opposite directions or to different degrees cause stenosis shape change with profound effects on fluid dynamic severity, not accounted for by simple percent narrowing. Accordingly, all stenosis dimensions were analyzed, including proximal, minimal, distal diameter, integrated length, exit angles and exit effects, determining stenosis shape and a single integrated measure of stenosis severity, stenosis flow reserve reflecting functional severity. In the control group, complex shape change and a stenosis- molding characteristic of statistically significant progressing severity occurred with worsening of stenosis flow reserve. In the treated group, complex shape change and stenosis molding characteristic of significant regressing severity was observed with improved stenosis flow reserve, there-by documenting the multidimensional characteristics of regressing coronary artery disease in humans. |
| Document Type: Article |
| Language: English |
| Reprint Address: GOULD, KL (reprint author), UNIV TEXAS, SCH MED, DIV CARDIOL, ROOM 4258 MSMB, BOX 2078, HOUSTON, TX 77225 USA |
Addresses:
1. UNIV CALIF SAN FRANCISCO, CALIF PACIFIC MED CTR, PREVENT MED RES INST, SAN FRANCISCO, CA 94143 USA
2. UNIV CALIF BERKELEY, BERKELEY, CA 94720 USA |
| Publisher: EXCERPTA MEDICA INC, 245 WEST 17TH STREET, NEW YORK, NY 10011 |
| Subject Category: Cardiac & Cardiovascular Systems |
| IDS Number: HL061 |
| ISSN: 0002-9149 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |