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| THE MECHANISM OF ACTION OF CYCLOSPORINE-A AND FK506 |
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| Author(s): SCHREIBER SL, CRABTREE GR |
| Source: IMMUNOLOGY TODAY Volume: 13 Issue: 4 Pages: 136-142 Published: APR 1992 |
| Times Cited: 1,524 References: 80 |
| Abstract: CsA and FK506 are powerful suppressors of the immune system, most notably of T cells. They act at a point in activation that lies between receptor ligation and the transcription of early genes. Here, Stuart Schreiber and Gerald Crabtree review recent findings that indicate CsA and FK506 operate as prodrugs: they bind endogenous intracellular receptors, the immunophilins, and the resulting complex targets the protein phosphatase, calcineurin, to exert the immunosuppressive effect. |
| Document Type: Review |
| Language: English |
| Reprint Address: SCHREIBER, SL (reprint author), HARVARD UNIV, DEPT CHEM, CAMBRIDGE, MA 02138 USA |
Addresses:
1. STANFORD UNIV, HOWARD HUGHES MED INST, MOLEC & GENET MED UNIT, STANFORD, CA 94305 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Immunology |
| IDS Number: HM443 |
| ISSN: 0167-5699 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |