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| A POPULATION OF EARLY FETAL THYMOCYTES EXPRESSING FC-GAMMA-RII/III CONTAINS PRECURSORS OF LYMPHOCYTES-T AND NATURAL-KILLER-CELLS |
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| Author(s): RODEWALD HR, MOINGEON P, LUCICH JL, DOSIOU C, LOPEZ P, REINHERZ EL |
| Source: CELL Volume: 69 Issue: 1 Pages: 139-150 Published: APR 3 1992 |
| Times Cited: 248 References: 97 |
| Abstract: We have identified a dominant fetal thymocyte population at day 14.5 of gestation in the mouse that lacks CD4 and CD8 but expresses Fc-gamma-RII/III+ several days prior to acquisition of the T cell receptor (TCR) in vivo. If maintained in a thymic microenvironment, this population of CD4-CD8-TCR-Fc-gamma-RII/III+ thymocytes differentiates first into CD4+CD8+TCR(low)Fc-gamma-RII/III- thymocytes and subsequently CD4+CD8-TCR(high)Fc-gamma-RII/III- and CD4-CD8+TCR(high)Fc-gamma-RII/III mature Ti alpha-beta lineage T cells. However, if removed from the thymus, the CD4-CD8-TCR-Fc-gamma-RII/III+ thymocyte population selectively generates functional natural killer (NK) cells in vivo as well as in vitro. These findings show that a cellular pool of Fc-gamma-RII/III+ precursors gives rise to T and NK lineages in a microenvironment-dependent manner. Moreover, they suggest a hitherto unrecognized role for Fc receptors on primitive T cells. |
| Document Type: Article |
| Language: English |
| Reprint Address: RODEWALD, HR (reprint author), HARVARD UNIV, SCH MED, DANA FARBER CANC INST, IMMUNOBIOL LAB, 44 BINNEY ST, BOSTON, MA 02115 USA |
Addresses:
1. HARVARD UNIV, SCH MED, DANA FARBER CANC INST, FLOW CYTOMETRY FACIL, BOSTON, MA 02115 USA
2. HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA
3. HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: HM445 |
| ISSN: 0092-8674 |
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