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| CAENORHABDITIS-ELEGANS GENE CED-9 PROTECTS CELLS FROM PROGRAMMED CELL-DEATH |
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| Author(s): HENGARTNER MO, ELLIS RE, HORVITZ HR |
| Source: NATURE Volume: 356 Issue: 6369 Pages: 494-499 Published: APR 9 1992 |
| Times Cited: 600 References: 40 |
| Abstract: The gene ced-9 of the nematode Caenorhabditis elegans acts to protect cells from programmed cell death. A mutation that abnormally activates ced-9 prevents the cell deaths that occur during normal C. elegans development. Conversely, mutations that inactivate ced-9 cause cells that normally live to undergo programmed cell death; these mutations result in embryonic lethality, indicating that ced-9 function is essential for development. The ced-9 gene functions by negatively regulating the activities of other genes that are required for the process of programmed cell death. |
| Document Type: Article |
| Language: English |
| Reprint Address: HENGARTNER, MO (reprint author), MIT, HOWARD HUGHES MED INST, DEPT BIOL, ROOM 56-629, 77 MASSACHUSETTS AVE, CAMBRIDGE, MA 02139 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: HN231 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |