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| STRUCTURE AND EXPRESSION OF A HUMAN OXYTOCIN RECEPTOR |
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| Author(s): KIMURA T, TANIZAWA O, MORI K, BROWNSTEIN MJ, OKAYAMA H |
| Source: NATURE Volume: 356 Issue: 6369 Pages: 526-529 Published: APR 9 1992 |
| Times Cited: 414 References: 27 |
| Abstract: JUST before the onset of labour, uterine myometrium becomes extremely sensitive to oxytocin 1, for which it is a primary target tissue, because of a dramatic increase in the number of oxytocin receptors 2,3. We report here the structure and expression of the human oxytocin receptor complementary DNA isolated by expression cloning. The encoded receptor is a 388-amino-acid polypeptide with 7 transmembrane domains typical of G protein-coupled receptors. The oxytocin receptor, expressed in Xenopus oocytes, specifically responds to oxytocin and induces an inward membrane current. Messenger RNAs for the receptor are of two sizes, 3.6 kilobases in breast, and 4.4 kilobases in ovary, uterine endometrium and myometrium. The mRNA level in the myometrium is very high at term. We conclude that the increase in receptor number in the myometrium at labour is, at least in part, due to the increase in mRNA. |
| Document Type: Article |
| Language: English |
| Reprint Address: KIMURA, T (reprint author), OSAKA UNIV, SCH MED, DEPT OBSTET & GYNECOL, 1-1-50 FUKUSHIMA, FUKUSHIMA KU, OSAKA 553, JAPAN |
Addresses:
1. OSAKA BIOSCI INST, DEPT NEUROSCI, SUITA, OSAKA 565 JAPAN
2. NIMH, CELL BIOL LAB, BETHESDA, MD 20892 USA
3. OSAKA UNIV, MICROBIAL DIS RES INST, DEPT MOLEC GENET, SUITA, OSAKA 565 JAPAN |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: HN231 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |