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| MAGNESIUM-DEFICIENCY ELEVATES CIRCULATING LEVELS OF INFLAMMATORY CYTOKINES AND ENDOTHELIN |
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| Author(s): WEGLICKI WB, PHILLIPS TM, FREEDMAN AM, CASSIDY MM, DICKENS BF |
| Source: MOLECULAR AND CELLULAR BIOCHEMISTRY Volume: 110 Issue: 2 Pages: 169-173 Published: MAR 25 1992 |
| Times Cited: 128 References: 22 |
| Abstract: We have developed two rodent models of diet-induced magnesium-deficiency in which histologically defined cardiac lesions can be induced within two to three weeks. During the development of these lesions, the magnesium-deficient animals exhibit circulating cytokine levels which are indicative of a generalized inflammatory state. Dramatic elevations of the macrophage-derived cytokines, IL-1, IL-6, and TNF-alpha together with significantly elevated levels of the endothelial cell-derived cytokine, endothelin, were detected in the plasma of these animals. We believe that the pathophysiological effects caused by the action of these cytokines may play a role in the promotion of cardiovascular pathology associated with magnesium deficiency. |
| Document Type: Article |
| Language: English |
| Reprint Address: WEGLICKI, WB (reprint author), GEORGE WASHINGTON UNIV, MED CTR, DEPT PHYSIOL, ROOM 402, ROSS HALL, 2300 EYE ST NW, WASHINGTON, DC 20037 USA |
Addresses:
1. GEORGE WASHINGTON UNIV, MED CTR, DEPT MED, WASHINGTON, DC 20037 USA |
| Publisher: KLUWER ACADEMIC PUBL, SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS |
| Subject Category: Cell Biology |
| IDS Number: HN700 |
| ISSN: 0300-8177 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |