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| HUMAN PAPILLOMAVIRUS TYPE-16 DNA IN CERVICAL SMEARS AS PREDICTOR OF HIGH-GRADE CERVICAL-CANCER |
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| Author(s): CUZICK J, TERRY G, HO L, HOLLINGWORTH T, ANDERSON M |
| Source: LANCET Volume: 339 Issue: 8799 Pages: 959-960 Published: APR 18 1992 |
| Times Cited: 127 References: 10 |
| Abstract: The management of women with mild to moderately dyskaryotic cervical smears would benefit from a non-invasive test that predicts which women have high-grade cervical intraepithelial neoplasia. Detection of human papillomavirus type 16 (HPV16) DNA in cervical smears may be such a test. With the polymerase chain reaction (PCR), we estimated the amount of HPV16 DNA in cervical smears from 85 women referred for colposcopy because of abnormal cytology. An intermediate or high amount of HPV16 DNA predicted the presence of high-grade cervical intraepithelial neoplasia in a subsequent biopsy in almost 90% of patients irrespective of the cytological grade of the referral smear. This technique may allow early identification of those women with low-grade cytological abnormalities who have high-grade underlying cervical disease |
| Document Type: Note |
| Language: English |
| Reprint Address: CUZICK, J (reprint author), IMPERIAL CANC RES FUND, POB 123, LONDON WC2A 3PX, ENGLAND |
Addresses:
1. UNIV LONDON UNIV COLL, DEPT CHEM PATHOL, LONDON WC1E 6BT, ENGLAND
2. UNIV LONDON UNIV COLL, DEPT MED MICROBIOL, LONDON WC1E 6BT, ENGLAND
3. UNIV NOTTINGHAM HOSP, DEPT OBSTET, NOTTINGHAM NG7 2UH, ENGLAND
4. UNIV NOTTINGHAM HOSP, DEPT PATHOL, NOTTINGHAM NG7 2UH, ENGLAND |
| Publisher: LANCET LTD, 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL |
| Subject Category: Medicine, General & Internal |
| IDS Number: HP036 |
| ISSN: 0140-6736 |
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