| | |  | | | | Record from Web of Science® | | | | | | |
| INHIBITION OF MESANGIAL CELL-PROLIFERATION AND MATRIX EXPANSION IN GLOMERULONEPHRITIS IN THE RAT BY ANTIBODY TO PLATELET-DERIVED GROWTH-FACTOR |
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| Author(s): JOHNSON RJ, RAINES EW, FLOEGE J, YOSHIMURA A, PRITZL P, ALPERS C, ROSS R |
| Source: JOURNAL OF EXPERIMENTAL MEDICINE Volume: 175 Issue: 5 Pages: 1413-1416 Published: MAY 1 1992 |
| Times Cited: 326 References: 14 |
| Abstract: Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells in culture, is expressed in vivo in a variety of inflammatory conditions associated with cell proliferation, including atherosclerosis, wound repair, pulmonary fibrosis, and glomerulonephritis. However, it is not known if PDGF mediates the fibroproliferative responses that characterize these inflammatory disorders. We administered neutralizing anti-PDGF IgG or control IgG to rats with mesangial proliferative nephritis. Inhibition of PDGF resulted in a significant reduction in mesangial cell proliferation, and largely prevented the increased deposition of extracellular matrix associated with the disease. This suggests that PDGF may have a central role in proliferative glomerular disease. |
| Document Type: Note |
| Language: English |
| Reprint Address: JOHNSON, RJ (reprint author), UNIV WASHINGTON, SCH MED, MED CTR, DEPT MED, DIV NEPHROL, RM-11, SEATTLE, WA 98195 USA |
Addresses:
1. UNIV WASHINGTON, MED CTR, DEPT PATHOL, DIV NEPHROL, SEATTLE, WA 98195 USA |
| Publisher: ROCKEFELLER UNIV PRESS, 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 |
| Subject Category: Immunology; Medicine, Research & Experimental |
| IDS Number: HQ184 |
| ISSN: 0022-1007 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |