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| ANONYMOUS MARKERS LOCATED ON CHROMOSOME-6 IN THE HLA-A CLASS-I REGION - ALLELIC DISTRIBUTION IN GENETIC HEMOCHROMATOSIS |
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| Author(s): BORETTO J, JOUANOLLE AM, YAOUANQ J, ELKAHLOUN A, MAUVIEUX V, BLAYAU M, PERICHON M, LETREUT A, CLAYTON J, BOROT N, LEGALL JY, PONTAROTTI P, DAVID V |
| Source: HUMAN GENETICS Volume: 89 Issue: 1 Pages: 33-36 Published: APR 1992 |
| Times Cited: 30 References: 22 |
| Abstract: Two yeast artificial chromosomes of the HLA class I region were subcloned. Four of the subclones studied displayed restriction polymorphisms that corresponded to six bi-allelic series. Allelic distribution of the anonymous markers was then studied by comparing a control population with a group of patients with familial haemochromatosis. Only one marker presents an unequivocal association with the haemochromatosis gene and is 100 kb centromeric to HLA-A. This association however is not as strong as with HLA-A3. The results suggest two possible locations for the haemochromatosis gene: less than 100 kb centromeric to the HLA-A locus, or on the telomeric side. |
| Document Type: Article |
| Language: English |
Addresses:
1. FAC MED RENNES, BIOCHIM MED B LAB, F-35043 RENNES, FRANCE
2. CNRS, INSERM, CTR IMMUNOL, F-13288 MARSEILLE 9, FRANCE
3. CHU RENNES, MED F CHU, F-35000 RENNES, FRANCE
4. CHU PURPAN, CNRS, UPR 8291, F-31300 TOULOUSE, FRANCE |
| Publisher: SPRINGER VERLAG, 175 FIFTH AVE, NEW YORK, NY 10010 |
| Subject Category: Genetics & Heredity |
| IDS Number: HQ684 |
| ISSN: 0340-6717 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |