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| CONFIRMATION OF LINKAGE OF BENIGN FAMILIAL NEONATAL CONVULSIONS TO D20S19 AND D20S20 |
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| Author(s): MALAFOSSE A, LEBOYER M, DULAC O, NAVELET Y, PLOUIN P, BECK C, LAKLOU H, MOUCHNINO G, GRANDSCENE P, VALLEE L, GUILLOUDBATAILLE M, SAMOLYK D, BALDYMOULINIER M, FEINGOLD J, MALLET J |
| Source: HUMAN GENETICS Volume: 89 Issue: 1 Pages: 54-58 Published: APR 1992 |
| Times Cited: 74 References: 19 |
| Abstract: Benign familial neonatal convulsions (BFNC) is an idiopathic form of epilepsy beginning within the first six months of life. Its genetic origin and autosomal dominant mode of inheritance have been suspected since its first description. Recently, the BFNC gene has been localised within chromosome 20q in one large pedigree. For the first time, we confirm here (with D20S19 and D20S20) the close linkage of BFNC to chromosome 20q in six French pedigrees. In addition, the existence in these families of several cases of febrile convulsions (FC), another epileptic syndrome with an autosomal dominant genetic component, led us to study the possibility of a genetic background identical to BFNC. Our results suggest the existence of different susceptibility genes for BFNC and FC. |
| Document Type: Article |
| Language: English |
| Reprint Address: MALAFOSSE, A (reprint author), LAB MED EXPTL, CNRS, UPR 41, INSERM, F-34060 MONTPELLIER, FRANCE |
Addresses:
1. HOP ST VINCENT DE PAUL, SERV NEUROPEDIAT, F-75674 PARIS 14, FRANCE
2. CNRS, NEUROBIOL CELLULAIRE & MOLEC LAB, F-91198 GIF SUR YVETTE, FRANCE
3. HOP RENE DUBOS, SERV NEONATOL, F-95300 PONTOISE, FRANCE
4. HOP CALMETTES, SERV NEUROPEDIAT, F-59000 LILLE, FRANCE
5. HOP ST VINCENT DE PAUL, INSERM, U29, F-75674 PARIS 14, FRANCE
6. HOP BICETRE, SERV EXPLORAT FONCT SYST NERVEUX, F-94275 LE KREMLIN BICETR, FRANCE |
| Publisher: SPRINGER VERLAG, 175 FIFTH AVE, NEW YORK, NY 10010 |
| Subject Category: Genetics & Heredity |
| IDS Number: HQ684 |
| ISSN: 0340-6717 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |