| | |  | | | | Record from Web of Science® | | | | | | |
| MITOCHONDRIAL GENETICS - A PARADIGM FOR AGING AND DEGENERATIVE DISEASES |
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| Author(s): WALLACE DC |
| Source: SCIENCE Volume: 256 Issue: 5057 Pages: 628-632 Published: MAY 1 1992 |
| Times Cited: 885 References: 85 |
| Abstract: Studies of diseases caused by mitochondrial DNA mutations suggest that a variety of degenerative processes may be associated with defects in oxidative phosphorylation (OXPHOS). Application of this hypothesis has provided new insights into such diverse clinical problems as ischemic heart disease, late-onset diabetes, Parkinson's disease, Alzheimer's disease, and aging. |
| Document Type: Article |
| Language: English |
| Reprint Address: WALLACE, DC (reprint author), EMORY UNIV, SCH MED, DEPT GENET & MOLEC MED, ATLANTA, GA 30322 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: HR185 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |