| | |  | | | | Record from Web of Science® | | | | | | |
| SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1 IS RELEASED BY HUMAN-MELANOMA CELLS AND IS ASSOCIATED WITH TUMOR-GROWTH IN NUDE-MICE |
|
|
| Author(s): GIAVAZZI R, CHIRIVI RGS, GAROFALO A, RAMBALDI A, HEMINGWAY I, PIGOTT R, GEARING AJH |
| Source: CANCER RESEARCH Volume: 52 Issue: 9 Pages: 2628-2630 Published: MAY 1 1992 |
| Times Cited: 97 References: 15 |
| Abstract: We have studied the cytokine regulation of cell surface and soluble intercellular adhesion molecule 1 (ICAM-1) expression on the human melanoma cell line A375M. Unstimulated cells express ICAM-1 on their cell surface but do not secrete significant levels of soluble ICAM-1. Interleukin 1, interleukin 6, tumor necrosis factor, and gamma-interferon all increased cell surface expression of ICAM-1. Tumor necrosis factor, interleukin 1, and gamma-interferon also caused the release of soluble ICAM-1. The serum of melanoma patients has been reported to contain elevated levels of soluble ICAM-1; however, the source of this ICAM-1 is unclear. The serum from nude mice bearing s.c. human melanoma tumors was found to contain soluble human ICAM-1. ICAM-1 levels showed a positive correlation with tumor weight. The release of ICAM-1 from melanoma tumors, in response to host-derived cytokines, may have relevance to immune recognition of the tumor. |
| Document Type: Note |
| Language: English |
| Reprint Address: GIAVAZZI, R (reprint author), MARIO NEGRI INST PHARMACOL RES, VIA GAVAZZENI 11, I-24100 BERGAMO, ITALY |
Addresses:
1. BRITISH BIOTECHNOL LTD, COWLEY, OXON ENGLAND |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology |
| IDS Number: HR290 |
| ISSN: 0008-5472 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |