| | |  | | | | Record from Web of Science® | | | | | | |
| CYSTIC-FIBROSIS - MOLECULAR-BIOLOGY AND THERAPEUTIC IMPLICATIONS |
|
|
| Author(s): COLLINS FS |
| Source: SCIENCE Volume: 256 Issue: 5058 Pages: 774-779 Published: MAY 8 1992 |
| Times Cited: 540 References: 75 |
| Abstract: Cystic fibrosis is the most common potentially lethal autosomal recessive disease of Caucasians, affecting 1 in 2500 newborns. Since the recent identification of the gene that is defective in patients with cystic fibrosis, a wealth of information about gene structure, the mutational basis of disease, and the function of the protein product ha's been derived. The product of the gene is a chloride channel that is regulated by adenosine 3',5'-monophosphate (cyclic AMP)-dependent protein kinase phosphorylation and that requires binding of adenosine triphosphate (ATP) for channel opening. Several new approaches to drug therapy for cystic fibrosis are now emerging, and the possibility of successful gene therapy by transfer of the normal gene to airway epithelial cells is being vigorously pursued. |
| Document Type: Article |
| Language: English |
| Reprint Address: COLLINS, FS (reprint author), UNIV MICHIGAN, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA |
Addresses:
1. UNIV MICHIGAN, HOWARD HUGHES MED INST, ANN ARBOR, MI 48109 USA
2. UNIV MICHIGAN, DEPT HUMAN GENET, ANN ARBOR, MI 48109 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: HT235 |
| ISSN: 0036-8075 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |