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| THE RETINOBLASTOMA GENE IN BREAST-CANCER - ALLELE LOSS IS NOT CORRELATED WITH LOSS OF GENE PROTEIN EXPRESSION |
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| Author(s): BORG A, ZHANG QX, ALM P, OLSSON H, SELLBERG G |
| Source: CANCER RESEARCH Volume: 52 Issue: 10 Pages: 2991-2994 Published: MAY 15 1992 |
| Times Cited: 100 References: 32 |
| Abstract: The significance of the retinoblastoma gene (RB) in the development of human breast cancer remains unclear. In the present study, loss of heterozygosity (LOH) in RB was found in 26% of 90 informative primary breast tumors and was correlated to DNA nondiploidy, a high S-phase fraction, and LOH at chromosome 17p13.3. However, allele loss was not associated with loss of RB protein (pRB) expression. Low to absent levels of pRB were found in 15% of 73 immunoblot analyzed tumors, most of which manifested retained heterozygosity in RB. Conversely, tumors exhibiting LOH showed often high pRB expression. Our data suggest that RB may be involved in the pathogenesis of some breast tumors, as evidenced by the absence of pRB, but that this alteration is acquired by mechanisms other than the unmasking of a recessive mutation by allele loss. LOH in RB may be merely a stochastic event in the unstable genome of aneuploid, rapidly proliferating cells or, alternatively, reflect the presence of an adjacent tumor suppressor gene. |
| Document Type: Note |
| Language: English |
| Reprint Address: BORG, A (reprint author), UNIV LUND HOSP, DEPT ONCOL, S-22185 LUND, SWEDEN |
Addresses:
1. UNIV LUND HOSP, DEPT PATHOL, S-22185 LUND, SWEDEN |
| Publisher: AMER ASSOC CANCER RESEARCH, 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA |
| Subject Category: Oncology |
| IDS Number: HU222 |
| ISSN: 0008-5472 |
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