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| LONG-TERM POTENTIATION IS ASSOCIATED WITH INCREASES IN QUANTAL CONTENT AND QUANTAL AMPLITUDE |
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| Author(s): KULLMANN DM, NICOLL RA |
| Source: NATURE Volume: 357 Issue: 6375 Pages: 240-244 Published: MAY 21 1992 |
| Times Cited: 204 References: 31 |
| Abstract: LONG-TERM potentiation (LTP) of synaptic transmission in CA1 neurons of the hippocampus, elicited by the conjunction of presynaptic firing and postsynaptic depolarization, is an important model of plasticity, which may underlie memory storage 1-3. Although induction of LTP takes place in the postsynaptic cell 4-7, it is not clear whether it is expressed through an enhancement of transmitter release 8-12 or through an increased postsynaptic response to the same amount of transmitter 13-16. Analysis of the trial-to-trial amplitude fluctuations of synaptic signals, that is quantal analysis, gives an important insight into the probabilistic mechanisms of transmission, although attempts to apply it to the mode of expression of LTP have so far yielded inconsistent results 9-12,15, at least in part because they have relied on models of transmitter release that have not been confirmed experimentally 17-19. Here we report clear evidence for quantal fluctuation in a subset of cells. Induction of LTP in these cells causes abrupt increases in either quantal content or quantal amplitude, or both. This shows that two different mechanisms can underlie the maintenance of LTP. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV CALIF SAN FRANCISCO, SCH MED, DEPT PHARMACOL, SAN FRANCISCO, CA 94143 USA
2. UNIV CALIF SAN FRANCISCO, SCH MED, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: HV195 |
| ISSN: 0028-0836 |
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