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| NEW RECOMBINANT HLA-B ALLELES IN A TRIBE OF SOUTH-AMERICAN AMERINDIANS INDICATE RAPID EVOLUTION OF MHC CLASS-I LOCI |
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| Author(s): WATKINS DI, MCADAM SN, LIU XM, STRANG CR, MILFORD EL, LEVINE CG, GARBER TL, DOGON AL, LORD CI, GHIM SH, TROUP GM, HUGHES AL, LETVIN NL |
| Source: NATURE Volume: 357 Issue: 6376 Pages: 329-333 Published: MAY 28 1992 |
| Times Cited: 221 References: 37 |
| Abstract: EVIDENCE suggests that the New World was colonized only 11,000-40,000 years ago by Palaeo-Indians 1. The descendants of these Palaeo-Indians therefore provide a unique opportunity to study the effects of selection on major histocompatibility complex class I genes over a short period. Here we analyse the class I alleles of the Waorani of South America and the Zuni of North America. Four of the Waorani HLA-B alleles were new functional variants which could be accounted for by intralocus recombination. In contrast, all of the Zuni HLA-A and -B molecules were present in caucasians and orientals. This suggests that the new Waorani HLA-B variants arose in South America. The description of four new HLA-B alleles in the Waorani and another five new HLA-B alleles from two other tribes of South American Amerindians 2 indicates that the HLA-B locus can evolve rapidly in isolated populations. These studies underline the importance of gathering genetic data on endangered native human populations 3. |
| Document Type: Article |
| Language: English |
| Reprint Address: WATKINS, DI (reprint author), HARVARD UNIV, SCH MED, NEW ENGLAND REG PRIMATE RES CTR, 1 PINE HILL DR, SOUTHBOROUGH, MA 01772 USA |
Addresses:
1. BRIGHAM & WOMENS HOSP, BOSTON, MA 02115 USA
2. TEXAS A&M UNIV SYST, COLL VET MED, COLLEGE STN, TX 77843 USA
3. UNIV NEW MEXICO, SCH MED, DEPT PATHOL, ALBUQUERQUE, NM 87131 USA
4. PENN STATE UNIV, DEPT BIOL, MUELLER LAB 208, UNIV PK, PA 16802 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: HW132 |
| ISSN: 0028-0836 |
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