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| CLONING AND CHARACTERIZATION OF A VASOPRESSIN V2 RECEPTOR AND POSSIBLE LINK TO NEPHROGENIC DIABETES-INSIPIDUS |
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| Author(s): LOLAIT SJ, OCARROLL AM, MCBRIDE OW, KONIG M, MOREL A, BROWNSTEIN MJ |
| Source: NATURE Volume: 357 Issue: 6376 Pages: 336-339 Published: MAY 28 1992 |
| Times Cited: 384 References: 28 |
| Abstract: THE antidiuretic effect of arginine vasopressin (AVP) is mediated by renal-type (V2) receptors linked to adenylyl cyclase 1. We report here the cloning of the rat kidney V2 AVP receptor complementary DNA that encodes a 370-amino-acid protein with a transmembrane topography characteristic of G protein-coupled receptors, and with similarity to the V1a (hepatic) AVP receptor 2 in its seven membrane-spanning domains. Expression of the cloned cDNA in mammalian cells showed specific ligand binding and activity characteristic of the native V2 AVP receptor. The receptor messenger RNA is detected only in the kidney. The human V2 receptor gene has been localized to the long arm of the X chromosome close to the locus for nephrogenic diabetes insipidus, an X-linked recessive disorder characterized by renal resistance to the antidiuretic action of AVP 3-6. |
| Document Type: Article |
| Language: English |
Addresses:
1. NIMH, CELL BIOL LAB, BLDG 36, ROOM 3A-17, BETHESDA, MD 20892 USA
2. GRP NEUROBIOCHIM CELLULAIRE & MOLEC, F-75006 PARIS, FRANCE
3. NCI, CHEM LAB, BETHESDA, MD 20892 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: HW132 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |