| MECHANISM OF GENITAL TRANSMISSION OF SIV - A HYPOTHESIS BASED ON TRANSMISSION STUDIES AND THE LOCATION OF SIV IN THE GENITAL-TRACT OF CHRONICALLY INFECTED FEMALE RHESUS MACAQUES |
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| Author(s): MILLER CJ, ALEXANDER NJ, VOGEL P, ANDERSON J, MARX PA |
| Source: JOURNAL OF MEDICAL PRIMATOLOGY Volume: 21 Issue: 2-3 Pages: 64-68 Published: FEB-MAY 1992 |
| Times Cited: 75 References: 20 |
| Abstract: To understand the biologic processes involved in transmission of HIV, we examined the genital tracts of chronically infected female macaques and localized SIV-infected cells. SIV was found in the genital tract of 12 of 16 animals and SIV-infected cells were located in the cervix and vagina. Inoculation of cell-free SIV into the blind vaginal pouch of hysterectomized macaques resulted in systemic infection. We propose a hypothesis to explain the early events in the genital transmission of SIV. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: MILLER, CJ (reprint author), UNIV CALIF DAVIS, CALIF PRIMATE RES CTR, DAVIS, CA 95616 USA |
Addresses:
1. NICHHD, BETHESDA, MD 20892 USA
2. NEW MEXICO STATE UNIV, NEW MEXICO REG PRIMATE RES LAB, LAS CRUCES, NM 88003 USA |
| Publisher: MUNKSGAARD INT PUBL LTD, 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK |
| Subject Category: Veterinary Sciences; Zoology |
| IDS Number: HW208 |
| ISSN: 0047-2565 |