| | |  | | | | Record from Web of Science® | | | | | | |
| BREAST-CANCER IN MEN - RISK-FACTORS WITH HORMONAL IMPLICATIONS |
|
|
| Author(s): THOMAS DB, JIMENEZ LM, MCTIERNAN A, ROSENBLATT K, STALSBERG H, STEMHAGEN A, THOMPSON WD, CURNEN MGM, SATARIANO W, AUSTIN DF, GREENBERG RS, KEY C, KOLONEL LN, WEST DW |
| Source: AMERICAN JOURNAL OF EPIDEMIOLOGY Volume: 135 Issue: 7 Pages: 734-748 Published: APR 1 1992 |
| Times Cited: 95 References: 56 |
| Abstract: Cases included in a population-based case-control study of breast cancer in men were recruited from 10 geographic areas of the United States from 1983 to 1986. Controls, matched to cases on age and geographic area, were selected by random digit dialing for men under age 65 years and from Health Care Financing Administration files for older men. Results are based on responses from 227 cases and 300 controls to questions asked in a standardized personal interview. An increased risk of breast cancer was most strongly associated with undescended testes and was also related to orchiectomy, orchitis, testicular injury, late puberty, and infertility; and a decreasing trend in risk was observed with an increasing number of children. Relative risk estimates were also elevated in relation to a history of high blood cholesterol, rapid weight gain, benign breast conditions, and possibly obesity. These findings suggest that breast cancer in men develops in response to androgen deficiency associated with testicular dysfunction and under conditions associated with excess estrogen. Risk was also found to be elevated in men with a history of amphetamine use, diabetes, and cigar smoking and reduced in men with prior head trauma. |
| Document Type: Article |
| Language: English |
| Reprint Address: THOMAS, DB (reprint author), FRED HUTCHINSON CANC RES CTR, PROGRAM EPIDEMIOL, MP-474, 1124 COLUMBIA ST, SEATTLE, WA 98104 USA |
Addresses:
1. UNIV GUADALAJARA, INST REG INVEST SALUD PUB, GUADALAJARA, JALISCO MEXICO
2. UNIV WASHINGTON, SCH MED, SEATTLE, WA 98195 USA
3. UNIV TROMSO, N-9001 TROMSO, NORWAY
4. CIBA GEIGY CORP, DIV PHARMACEUT, SUMMIT, NJ 07901 USA
5. CONNECTICUT CANC EPIDEMIOL UNIT, NEW HAVEN, CT USA
6. UNIV SO MAINE, PORTLAND, ME 04103 USA
7. UNIV CALIF BERKELEY, SCH PUBL HLTH, BERKELEY, CA 94720 USA
8. CALIF DEPT HLTH SERV, RESOURCE CANC EPIDEMIOL, EMERYVILLE, CA USA
9. NEW MEXICO TUMOR REGISTRY, ALBUQUERQUE, NM USA
10. CANC RES CTR HAWAII, EPIDEMIOL PROGRAM, HONOLULU, HI USA
11. NO CALIF CANC CTR, ALAMEDA, CA USA |
| Publisher: JOHNS HOPKINS UNIV SCHOOL HYGIENE PUB HEALTH, 111 MARKET PLACE, STE 840, BALTIMORE, MD 21202-6709 |
| Subject Category: Public, Environmental & Occupational Health |
| IDS Number: HW647 |
| ISSN: 0002-9262 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |