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| VERTICAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INFECTION - REACTIVITY OF MATERNAL SERA WITH GLYCOPROTEIN-120 AND 41 PEPTIDES FROM HIV TYPE-1 |
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| Author(s): UGEN KE, GOEDERT JJ, BOYER J, REFAELI Y, FRANK I, WILLIAMS WV, WILLOUGHBY A, LANDESMAN S, MENDEZ H, RUBINSTEIN A, KIEBEREMMONS T, WEINER DB |
| Source: JOURNAL OF CLINICAL INVESTIGATION Volume: 89 Issue: 6 Pages: 1923-1930 Published: JUN 1992 |
| Times Cited: 75 References: 36 |
| Abstract: The observation that approximately 70% of HIV-infected pregnant women do not transmit infection vertically suggests that antibody therapy may be effective in the prevention of transmission of HIV infection from mother to child. Currently, there is an incomplete understanding of the processes involved in vertical transmission of HIV infection. The elucidation of the serological basis of maternal immunity as it relates to protection from vertical transmission is the goal of this study. We have screened 20 maternal sera from HIV+ individuals of known vertical transmission status for reactivity with 31 peptides spanning the entire envelope glycoprotein of HIV-1. Of interest was reactivity to regions outside of the V3 loop of gp120. The findings have been examined in relationship to transmission status, as well as to in vitro anti-HIV-1 biological activity. Our results indicate that lack of vertical transmission is correlated with high viral neutralization activity, but not with antisyncytial activity nor with binding to the V3 peptides examined in this study. Also, the transmission group bound to fewer gp41 peptides when compared with the nontransmission group, suggesting that immune responses to gp41 may be important in preventing transmission. These findings may provide insights into the design of passive immunotherapies. |
| Document Type: Article |
| Language: English |
Addresses:
1. WISTAR INST, 3601 SPRUCE ST, PHILADELPHIA, PA 19104 USA
2. UNIV PENN, DEPT MED, PHILADELPHIA, PA 19104 USA
3. NCI, VIRAL EPIDEMIOL LAB, FREDERICK, MD 21701 USA
4. NICHHD, ROCKVILLE, MD 20852 USA
5. SUNY HLTH SCI CTR, BROOKLYN, NY 11203 USA
6. YESHIVA UNIV ALBERT EINSTEIN COLL MED, BRONX, NY 10461 USA |
| Publisher: ROCKEFELLER UNIV PRESS, 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 |
| Subject Category: Medicine, Research & Experimental |
| IDS Number: HX974 |
| ISSN: 0021-9738 |
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