| | |  | | | | Record from Web of Science® | | | | | | |
| THE ASSOCIATION OF BENIGN PROSTATIC HYPERPLASIA AND CANCER OF THE PROSTATE |
|
|
| Author(s): BOSTWICK DG, COONER WH, DENIS L, JONES GW, SCARDINO PT, MURPHY GP |
| Source: CANCER Volume: 70 Issue: 1 Pages: 291-301 Supplement: Suppl. S Published: JUL 1 1992 |
| Times Cited: 91 References: 79 |
| Abstract: There are a number of similarities between benign prostatic hyperplasia [BPH] and cancer. Both display a parallel increase in prevalence with patient age according to autopsy studies [86.2% and 43.6%, respectively, by the ninth decade], although cancer lags by 15-20 years. Both require androgens for growth and development, and both respond to antiandrogen treatment regimens. Most cancers arise in prostates with concomitant BPH [83.3%], and cancer is found incidentally in a significant number of transurethral prostatectomy [TURP] specimens [10%]. The clinical incidence of cancer arising in patients with surgically treated BPH is approximately 3%. BPH may be related to a subset of prostate cancer which arises in the transition zone, perhaps in association with atypical adenomatous hyperplasia [AAH]. It is important to exclude cancer in patients presenting with symptoms of bladder outlet obstruction presumably due to BPH. For such patients, we recommend digital rectal examination [DRE] and, at least in high-risk patients, serum prostate specific antigen [PSA] determination. Transrectal ultrasound [TRUS] should be employed in patients with elevated PSA levels to determine the volume of the prostate, the relative contribution of BPH to volume, and the PSA density [ratio of PSA level to volume]. Biopsy should be obtained from any area suspicious for cancer. Early detection and treatment of cancer when it is localized offers the greatest chance for cure. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: BOSTWICK, DG (reprint author), MAYO CLIN & MAYO FDN, DEPT LAB MED & PATHOL, ROCHESTER, MN 55905 USA |
Addresses:
1. KONINGIN ELISABETHLEI, ANTWERP, BELGIUM
2. HOWARD UNIV, WASHINGTON, DC 20059 USA
3. BAYLOR COLL MED, HOUSTON, TX 77030 USA
4. AMER CANC SOC, ATLANTA, GA USA
5. UNIV SO ALABAMA, COLL MED, MOBILE, AL 36688 USA
6. MOBILE UROL GRP, MOBILE, AL USA |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Oncology |
| IDS Number: JA174 |
| ISSN: 0008-543X |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |