| | |  | | | | Record from Web of Science® | | | | | | |
| CULTURED DERMAL PAPILLA CELLS INDUCE FOLLICLE FORMATION AND HAIR-GROWTH BY TRANSDIFFERENTIATION OF AN ADULT EPIDERMIS |
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| Author(s): REYNOLDS AJ, JAHODA CAB |
| Source: DEVELOPMENT Volume: 115 Issue: 2 Pages: 587-593 Published: JUN 1992 |
| Times Cited: 111 References: 36 |
| Abstract: Adult rat pelage follicle dermal papilla cells induced follicle neogenesis and external hair growth when associated with adult footpad skin epidermis. They thus demonstrated a capacity to completely change the structural arrangement and gene expression of adult epidermis - an ability previously undocumented for cultured adult cells. Isolation chambers ensured that de novo follicle formation must have occurred by eliminating the possibility of cellular contributions, and/or inductive influences, from local skin follicles. These findings argue against previous suggestions of vibrissa follicle specificity, and imply that the potential for hair follicle induction may be common to all adult papilla cells. |
| Document Type: Article |
| Language: English |
| Reprint Address: REYNOLDS, AJ (reprint author), UNIV DURHAM, DEPT BIOL SCI, SCI LABS, S RD, DURHAM DH1 3LE, ENGLAND |
Addresses:
1. UNIV DUNDEE, DEPT BIOL SCI, DUNDEE DD1 4HN, SCOTLAND |
| Publisher: COMPANY OF BIOLOGISTS LTD, BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE, CAMBS, ENGLAND CB4 4DL |
| Subject Category: Developmental Biology |
| IDS Number: JB718 |
| ISSN: 0950-1991 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |