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| ALDOSTERONE ENHANCES ANGIOTENSIN-II RECEPTOR-BINDING AND INOSITOL PHOSPHATE RESPONSES |
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| Author(s): ULLIAN ME, SCHELLING JR, LINAS SL |
| Source: HYPERTENSION Volume: 20 Issue: 1 Pages: 67-73 Published: JUL 1992 |
| Times Cited: 97 References: 22 |
| Abstract: Clinical states in which angiotensin II is increased are often associated with increases in mineralocorticoids. To determine the effects of mineralocorticoids on angiotensin II action, we examined the effects of aldosterone on angiotensin II receptor expression and function in cultured rat vascular smooth muscle cells. Incubation with aldosterone resulted in concentration- and time-dependent increases in angiotensin II receptor number, without changes in binding affinity. For example, incubation with 1-mu-M aldosterone for 40 hours resulted in 59% increases in angiotensin II receptor number. Increases in angiotensin II receptors were dependent on protein synthesis as evidenced by the time dependency of upregulation and inhibition by cycloheximide. Incubation with aldosterone resulted in enhanced angiotensin II-stimulated phospholipase C activation, as demonstrated by increases in angiotensin II-induced inositol phosphate responses in proportion to the increases in receptor number. In addition, aldosterone prevented angiotensin II-induced downregulation of angiotensin II surface receptors and angiotensin II desensitization of inositol phosphate formation. In summary, aldosterone 1) directly increased angiotensin II receptor number, 2) increased angiotensin II-stimulated inositol phosphate responses, and 3) prevented angiotensin II-induced downregulation and desensitization. In conclusion, aldosterone may potentiate the pressor responses of angiotensin II via effects on angiotensin II receptors. |
| Document Type: Article |
| Language: English |
Addresses:
1. MED UNIV S CAROLINA, CHARLESTON, SC 29425 USA
2. UNIV COLORADO, HLTH SCI CTR, DENVER, CO 80262 USA |
| Publisher: AMER HEART ASSOC, 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 |
| Subject Category: Peripheral Vascular Disease |
| IDS Number: JB928 |
| ISSN: 0194-911X |
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