| | |  | | | | Record from Web of Science® | | | | | | |
| INCREASED OSTEOCLAST DEVELOPMENT AFTER ESTROGEN LOSS - MEDIATION BY INTERLEUKIN-6 |
|
|
| Author(s): JILKA RL, HANGOC G, GIRASOLE G, PASSERI G, WILLIAMS DC, ABRAMS JS, BOYCE B, BROXMEYER H, MANOLAGAS SC |
| Source: SCIENCE Volume: 257 Issue: 5066 Pages: 88-91 Published: JUL 3 1992 |
| Times Cited: 903 References: 30 |
| Abstract: Osteoclasts, the cells that resorb bone, develop from hematopoietic precursors of the bone marrow under the control of factors produced in their microenvironment. The cytokine interleukin-6 can promote hematopoiesis and osteoclastogenesis. Interleukin-6 production by bone and marrow stromal cells is suppressed by 17-beta-estradiol in vitro. In mice, estrogen loss (ovariectomy) increased the number of colony-forming units for granulocytes and macrophages, enhanced osteoclast development in ex vivo cultures of marrow, and increased the number of osteoclasts in trabecular bone. These changes were prevented by 17-beta-estradiol or an antibody to interleukin-6. Thus, estrogen loss results in an interleukin-6-mediated stimulation of osteoclastogenesis, which suggests a mechanism for the increased bone resorption in postmenopausal osteoporosis. |
| Document Type: Article |
| Language: English |
Addresses:
1. DEPT VET AFFAIRS MED CTR, ENDOCRINOL & METAB SECT, INDIANAPOLIS, IN 46202 USA
2. ELI LILLY & CO, LILLY RES LAB, INDIANAPOLIS, IN 46285 USA
3. DNAX RES INST CELLULAR & MOLEC BIOL, PALO ALTO, CA 94304 USA
4. UNIV TEXAS, HLTH SCI CTR, DEPT PATHOL, SAN ANTONIO, TX 78284 USA
5. INDIANA UNIV, SCH MED, DEPT MED, INDIANAPOLIS, IN 46202 USA
6. INDIANA UNIV, SCH MED, DEPT BIOCHEM, INDIANAPOLIS, IN 46202 USA
7. INDIANA UNIV, SCH MED, CTR ONCOL, INDIANAPOLIS, IN 46202 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JC165 |
| ISSN: 0036-8075 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |