| | |  | | | | Record from Web of Science® | | | | | | |
| ROLE FOR C-MYC IN ACTIVATION-INDUCED APOPTOTIC CELL-DEATH IN T-CELL HYBRIDOMAS |
|
|
| Author(s): SHI YF, GLYNN JM, GUILBERT LJ, COTTER TG, BISSONNETTE RP, GREEN DR |
| Source: SCIENCE Volume: 257 Issue: 5067 Pages: 212-214 Published: JUL 10 1992 |
| Times Cited: 688 References: 48 |
| Abstract: Immature T cells and some T cell hybridomas undergo apoptotic cell death when activated through the T cell receptor complex, a phenomenon that is probably related to antigen induced negative selection of developing T cells. This activation-induced apoptosis depends on active protein and RNA synthesis in the dying cells, although none of the genes required for this process have previously been identified. Antisense oligonucleotides corresponding to c-myc block the constitutive expression of c-Myc protein in T cell hybridomas and interfere with all aspects of activation-induced apoptosis without affecting lymphokine production in these cells. These data indicate that c-myc expression is a necessary component of activation-induced apoptosis. |
| Document Type: Article |
| Language: English |
Addresses:
1. LA JOLLA INST ALLERGY & IMMUNOL, LA JOLLA, CA 92037 USA
2. UNIV ALBERTA, DEPT IMMUNOL, EDMONTON T6G 2H7, ALBERTA CANADA
3. ST PATRICKS COLL, DEPT BIOL, MAYNOOTH, KILDARE IRELAND |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JC585 |
| ISSN: 0036-8075 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |