| SYNTAXIN - A SYNAPTIC PROTEIN IMPLICATED IN DOCKING OF SYNAPTIC VESICLES AT PRESYNAPTIC ACTIVE ZONES |
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| Author(s): BENNETT MK, CALAKOS N, SCHELLER RH |
| Source: SCIENCE Volume: 257 Issue: 5067 Pages: 255-259 Published: JUL 10 1992 |
| Times Cited: 870 References: 43 |
| Abstract: Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Two 35-kilodalton proteins (p35 or syntaxins) were identified that interact with the synaptic vesicle protein p65 (synaptotagmin). The p35 proteins are expressed only in the nervous system, are 84 percent identical, include carboxyl-terminal membrane anchors, and are concentrated on the plasma membrane at synaptic sites. An antibody to p35 immunoprecipitated solubilized N-type calcium channels. The p35 proteins may function in docking synaptic vesicles near calcium channels at presynaptic active zones. |
| Document Type: Article |
| Language: English |
Addresses:
1. STANFORD UNIV, MED CTR, BECKMAN CTR MOLEC & GENET MED, STANFORD, CA 94305 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: JC585 |
| ISSN: 0036-8075 |