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| ABSENCE OF LINKAGE BETWEEN THE ANGIOTENSIN CONVERTING ENZYME LOCUS AND HUMAN ESSENTIAL-HYPERTENSION |
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| Author(s): JEUNEMAITRE X, LIFTON RP, HUNT SC, WILLIAMS RR, LALOUEL JM |
| Source: NATURE GENETICS Volume: 1 Issue: 1 Pages: 72-75 Published: APR 1992 |
| Times Cited: 338 References: 40 |
| Abstract: The angiotensin converting enzyme (ACE) is a key component of the renin angiotensin system that contributes to the regulation of blood pressure (BP). Recent demonstration of linkage between the ACE locus and elevated BP in a rat model of hypertension has further emphasized ACE as a candidate gene in human hypertension1,2,3. We report the localization of the ACF gene on the genetic map of chromosome 17, and identify an extremely polymorphic marker at the human growth hormone (hGH) locus which shows no recombination with ACE. We have found no evidence to support linkage between the ACE locus and hypertension, which suggests that mutations at the ACE locus do not commonly contribute to the pathogenesis of hypertension in our test population. |
| Document Type: Article |
| Language: English |
| Reprint Address: JEUNEMAITRE, X (reprint author), UNIV UTAH, HLTH SCI CTR, HOWARD HUGHES MED INST, SALT LAKE CITY, UT 84112 USA |
Addresses:
1. UNIV UTAH, HLTH SCI CTR, DEPT HUMAN GENET, SALT LAKE CITY, UT 84112 USA
2. BRIGHAM & WOMENS HOSP, DIV ENDOCRINE HYPERTENS, BOSTON, MA 02115 USA
3. HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
4. UNIV UTAH, CARDIOVASC GENET RES CLIN, SALT LAKE CITY, UT 84112 USA |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: JC978 |
| ISSN: 1061-4036 |
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