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| COMPLETE COVERAGE OF THE SCHIZOSACCHAROMYCES-POMBE GENOME IN YEAST ARTIFICIAL CHROMOSOMES |
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| Author(s): MAIER E, HOHEISEL JD, MCCARTHY L, MOTT R, GRIGORIEV AV, MONACO AP, LARIN Z, LEHRACH H |
| Source: NATURE GENETICS Volume: 1 Issue: 4 Pages: 273-277 Published: JUL 1992 |
| Times Cited: 85 References: 31 |
| Abstract: The genome of the fission yeast, Schizosaccharomyces pombe, consists of some 14 million base pairs of DNA contained in three chromosomes. On account of its excellent genetics we used it as a test system for a strategy designed to map mammalian chromosomes and genomes. Data obtained from hybridization fingerprinting established an ordered library of 1,248 yeast artificial chromosome clones with an average size of 535 kilobases. The clones fall into three contigs completely representing the three chromosomes of the organism. This work provides a high resolution physical and clone map of the genome, which has been related to available genetic and physical map information. |
| Document Type: Article |
| Language: English |
| Reprint Address: MAIER, E (reprint author), IMPERIAL CANC RES FUND, GENOME ANAL LAB, POB 123, LINCOLNS INN FIELDS, LONDON WC2A 3PX, ENGLAND |
Addresses:
1. JOHN RADCLIFFE HOSP, IMPERIAL CANC RES FUND, INST MOLEC MED, HUMAN GENET LAB, OXFORD OX3 9DU, ENGLAND |
| Publisher: NATURE PUBLISHING CO, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 |
| Subject Category: Genetics & Heredity |
| IDS Number: JC984 |
| ISSN: 1061-4036 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |