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| ELEVATED LEVELS OF PLASMA TRANSFORMING GROWTH-FACTOR-BETA IN PATIENTS WITH HEPATOCELLULAR-CARCINOMA |
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| Author(s): SHIRAI Y, KAWATA S, ITO N, TAMURA S, TAKAISHI K, KISO S, TSUSHIMA H, MATSUZAWA Y |
| Source: JAPANESE JOURNAL OF CANCER RESEARCH Volume: 83 Issue: 7 Pages: 676-679 Published: JUL 1992 |
| Times Cited: 67 References: 23 |
| Abstract: We measured the plasma transforming growth factor-beta (TGF-beta) concentration in 14 patients with human hepatocellular carcinoma (HCC) and 9 age-matched normal subjects using growth inhibition assay of mink lung epithelial cells. The calculated plasma TGF-beta concentration in the patients with HCC was 28.6+/-27.9 ng/ml (mean+/-SE), showing significant elevation compared with that in 9 normal subjects (5.3+/-3.3 ng/ml, P<0.01). In three cases, we could measure plasma TGF-beta levels before and after their treatment for HCC. The plasma TGF-beta levels decreased from 59.0 to 18.2 ng/ml after hepatic resection in one case, and from 24.0 to 10.7 ng/ml and from 12.4 to 3.4 ng/ml after transhepatic arterial embolization in the other two cases. These data indicate that plasma TGF-beta level is elevated in patients with HCC, probably due to release from HCC tissues. |
| Document Type: Note |
| Language: English |
| Reprint Address: SHIRAI, Y (reprint author), OSAKA UNIV, SCH MED, DEPT INTERNAL MED 2, 1-1-50 FUKUSHIMA, FUKUSHIMA KU, OSAKA 553, JAPAN |
| Publisher: JAPANESE CANCER ASSOCIATION, EDITORIAL OFFICE 7TH FLOOR, JOHKOH BLDG 2-23-11, KOISHIKAWA, TOKYO 112, JAPAN |
| Subject Category: Oncology |
| IDS Number: JE530 |
| ISSN: 0910-5050 |
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