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| INITIAL SAFETY AND IMMUNOGENICITY STUDIES OF AN ORAL RECOMBINANT ADENOHEPATITIS-B VACCINE |
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| Author(s): TACKET CO, LOSONSKY G, LUBECK MD, DAVIS AR, MIZUTANI S, HORWITH G, HUNG P, EDELMAN R, LEVINE MM |
| Source: VACCINE Volume: 10 Issue: 10 Pages: 673-676 Published: 1992 |
| Times Cited: 38 References: 23 |
| Abstract: Orally administered adenovirus may be a useful vaccine carrier of cloned antigens of other pathogens. A recombinant adenohepatitis vaccine Wy-Ad7HZ6-1, which expressed hepatitis B surface antigen and contained a large deletion in early region 3 (E3), was constructed and studied in humans. Volunteers received Wy-Ad7HZ6-1 (n = 3), adenovirus type 7 vaccine (n = 3) or placebo (n = 3). Recipients of Wy-Ad7HZ6-1 shed less vaccine virus in the stool for a shorter period and had a lower titre of anti-adenovirus type 7 antibodies than recipients of the adenovirus 7 vaccine. None of the three Wy-Ad7HZ6-1 vaccinees developed antibody to hepatitis B surface antigen after this one dose primary immunization regimen. The E3 region may be required for optimal enteric growth of adenovirus-vectored vaccines. |
| Document Type: Article |
| Language: English |
| Reprint Address: TACKET, CO (reprint author), UNIV MARYLAND, SCH MED, CTR VACCINE DEV, DEPT MED, BALTIMORE, MD 21201 USA |
Addresses:
1. WYETH AYERST RES, PHILADELPHIA, PA 19101 USA |
| Publisher: BUTTERWORTH-HEINEMANN LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Immunology; Medicine, Research & Experimental; Veterinary Sciences |
| IDS Number: JG343 |
| ISSN: 0264-410X |
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