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| HYALURONAN (HYALURONIC-ACID) AND HYALURONECTIN IN THE EXTRACELLULAR-MATRIX OF HUMAN BREAST CARCINOMAS - COMPARISON BETWEEN INVASIVE AND NONINVASIVE AREAS |
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| Author(s): BERTRAND P, GIRARD N, DELPECH B, DUVAL C, DANJOU J, DAUCE JP |
| Source: INTERNATIONAL JOURNAL OF CANCER Volume: 52 Issue: 1 Pages: 1-6 Published: AUG 19 1992 |
| Times Cited: 83 References: 33 |
| Abstract: We performed quantitative determination of the distribution of hyaluronan (hyaluronic acid, HA) and the HA-binding protein, hyaluronectin (HN), 2 components of the extracellular matrix of tumor desmoplasia, within 71 human breast carcinomas. Results showed that HA and HN were more elevated in tumoral than in non-tumoral adjacent tissue, and that the peripheral invasive area of tumors contained increased levels of HA and HN as compared with the central non-invasive area (p < 10(-3) and p < 10(-5) respectively). HN and HA levels of 61 ductal carcinomas were related to the histological grade of tumors; no significant difference was found between grades for HA; HN was found to be significantly lower in grade III than in grade II tumors (p < 0.01). HA and HN rates were correlated in grade I and grade II tumors and were not correlated in grade III. Mean percentage of HA saturation level by HN for whole tumors was found to be less than 4%, indicating that HA is essentially free of proteins and could be used as a target for cancer diagnosis or therapy. |
| Document Type: Article |
| Language: English |
| Reprint Address: BERTRAND, P (reprint author), CTR REG LUTTE CONTRE CANC HENRI BECQUEREL, RUE AMIENS, F-76038 ROUEN, FRANCE |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Oncology |
| IDS Number: JJ723 |
| ISSN: 0020-7136 |
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